Adam Bagg is Director of Hematology and Medical Director of Clinical Cancer Cytogenetics at the University of Pennsylvania where he is a Professor of Pathology and Laboratory Medicine, in the Division of Hematopathology (for which he served as Interim Director until June 2015). News & World Report he is in the top 1% of doctors in the United States.For the past 5 years he was voted by his peers as one of Philadelphia’s “Top Doctors”. In 2011, he was elected to Board of Directors of USCAP, having previously served on their education committee.
A marked down-regulation of α subunit was detected in glandular epithelium, whilst expression of βA and βB subunits was maintained.
This pattern was consistent in decidua from early pregnancy and additionally in endometrium from women using progestin-only contraceptives, either subdermal implants (Norplant) or levonorgestrel-releasing intrauterine systems (Lng-IUS).
Immunostaining was also observed for both βA and βB subunits in subpopulations of endometrial leukocytes, identified to be distinct subsets of macrophages, neutrophils and mast cells.
Potential paracrine roles for activins may be envisaged in facilitating tissue remodelling during decidualization, in tissue repair following menstruation, and additionally in modulating premenstrual inflammatory events.
Further, the regulatory role of progestin ) or directly into the uterine cavity, via a levonorgestrel-releasing intrauterine system (Lng-IUS; Mirena, Leiras Oy, Finland).